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Werner's Syndrome is caused by a genetic mutation in human DNA. The mutation of the gene, known as the WRN gene, is located on chromosome 8. The WRN gene is responsible for producing an exonuclease that assists in the replication, repair, recombination, and transcription of DNA. A mutation in this gene encodes the exonuclease incorrectly so it does not function properly. The body then relies on other exonucleases which ineffectively try to repair the DNA. This causes the DNA to become genetically unstable and results in advanced aging. |
This site was last updated 03/17/03