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HIV Vaccines

The Science and Ethics of HIV Vaccine Research

Our HIV Vaccines Curriculum Unit explores the scientific and ethical issues involved in clinical HIV vaccine trials using human research participants. The unit begins by examining students’ current knowledge of HIV, and by reviewing HIV structure and transmission. Next, it familiarizes students with types of vaccines and with challenges related to creating an HIV vaccine. Students are encouraged to explore issues related to human research participants using basic ethical principles and historical case studies. Lastly, global issues regarding the pandemic are explored to give the students an understanding of cultural issues involved in the spread of HIV. This cultural context introduces students to ethical dilemmas inherent in the selection of human participants in global vaccine trials. The lessons culminate in having students design their own hypothetical HIV vaccine clinical trial, based upon knowledge of HIV structure, vaccine characteristics, human research participants considerations, and global contexts.

The complete five-lesson HIV Vaccines Curriculum is now available free for download from the Lessons page.

In order for us to measure how our curriculum resources are being used, please take a moment to contact us and let us know the class or classes in which you're using our lessons.  

We also welcome feedback about our HIV Vaccines curriculum. We will not share your contact information with anyone.

Lessons

 This curriculum is available free of charge, but for demographic purposes, NWABR requests you fill out a short information form.

    Complete Lesson Plans
  • Complete Curriculum
    ENTIRECIRRICULUM_2008.pdf
  • Overview
    OVERVIEW_2008.pdf

    Overall Unit Plan

    Correlation to National Science Standards

  • Lesson One - What Do You Know and What Will You Do?
    LESSONONE_2008.pdf

    Lesson Plan One

    What Would You Do?  Opening Scenario

    Global Awareness of HIV Survey

    Avert Transmission Activity

    Pandemic Facing AIDS Video Questions

  • Lesson Two - HIV Structure/Life Cycle--Implications for Vaccine Development
    LESSONTWO_2008.pdf

    Lesson Plan Two

    HIV Life Cycle Activity

  • Lesson Three - Vaccines
    LESSONTHREE_2008.pdf

    Lesson Plan Three

    Vaccine Type Table

  • Lesson Four - Case Studies and Human Research Ethics
    LESSONFOUR_2008.pdf

    Lesson Plan Four

    Case Study 1:  Yellow Fever

    Case Study 2:  Nazi Experiments

    Case Study 3:  Syphilis in African-American Men

    Case Study 4:  AZT and Pregnant Women in Africa

    Case Study 5:  Behaviour in Young Boys

    Historical Case Studies for Human Research Guiding Questions

    Student Handouts for Guidelines Activity

  • Lesson Five - Global Awareness Activity
    LESSONFIVE_2008.pdf

    Lesson Plan Five

    Global Awareness Activity Region and Country Cards

    Supporting Materials
  • Front Cover
    COVER_2008.pdf
  • Assessment
    ASSESSMENT_LESSONSIX_2008.pdf

    Culminating Assessments Overview

    Essay Rubric

    Presentation Student Introduction--Designing a Vaccine Trial

    Group Presentation Rubric

    Alternate Assessment--Evaluating an IRB Application

    IRB Application

    IRB Rubric

    Key for Alternate Assessment

  • Appendix
    APPENDIX_2008.pdf

    Declaration of Helsinki

    Review of HIV

    Review of Immune System

    Making an HIV Vaccine

    HIV Preventative Vaccine Background

    HIV Vaccine Brochure

  • HIV Mock Elisa Lab Activity
    HIV_MOCK_ELISA.doc
  • Understanding Vaccines NIH Pamphlet
    Understanding_Vaccines_NIH_Pamphlet.pdf
Resources

NWABR HIV Slideshow/Animations
Designed to be used with our HIV Vaccine Curriculum, these new slideshow/animations made in collaboration with the Genetic Science Learning Center show two different aspects of vaccines.

Types of Vaccines
What are the different types of vaccines?  What are the advantages and disadvantages of each type?  Which types are being pursued for an HIV vaccine?

Why is Making an HIV Vaccine so Hard?
This interactive animation explores the scientific challenges faced by researchers in developing an HIV vaccine.

HIV Vaccine Research Powerpoint
By:  Dr. Dina Kovarik, NWABR Program Manager

Links
  • http://www.sumanasinc.com/webcontent/animations/content/lifecyclehiv.html

    Sumanas Inc. HIV Animation Used with Lesson 2 of our HIV Vaccine Curriculum

  • http://www.pbs.org/wgbh/nova/aids/action.html

    NOVA PBS Animation Used with Lesson 2 of our HIV Vaccine Curriculum.

  • http://www.learner.org/courses/biology/units/hiv/images.html

    Quicktime Movies and Images

  • http://www.learner.org/courses/biology/units/hiv/index.html

    Streaming Video (see "View Video Online" icon at the bottom of the page)

  • http://www.pbs.org/wgbh/pages/frontline/aids/

    Frontline--The Age of AIDS 4 hours of free online video in 15 segments, many additional resources such as global maps

  • http://www.pbs.org/wgbh/rxforsurvival/series/video/index.html

    Rx for Survival Video Clips Many short clips about HIV vaccines as well as global contexts

  • http://www.pbs.org/wgbh/rxforsurvival/series/atlas/index.html

    Global Health Atlas allows students to explore connections between social and economic indicators and HIV

  • http://www.pbs.org/wgbh/rxforsurvival/series/teachers/index.html

    Teacher Lesson Plans are also provided

  • http://www.hvtn.org/

    HIV Vaccine Trials Network

  • http://www.seattlevaccines.org/

    HIV Vaccine Trials Unit--Seattle

  • /sites/default/files/learn/hivvaccine/Lewinsohn.ppt

    Global Impact of HIV/AIDS Deborah Lewinsohn, M.D. (OHSU) (1.5 MB)

  • http://www.aidsinfo.nih.gov/

    AIDSinfo is a U.S. Department of Health and Human Services (DHHS) project providing information on HIV/AIDS clinical trials and treatment

  • http://www.avert.org/

    Avert, an international HIV/AIDS charity, presents statistics and other useful information. Of particular interest is the collection of photos and images

  • http://www.cdc.gov/hiv/dhap.htm

    The division of HIV/AIDS prevention at the CDC presents basic science, statistics, answers to FAQs, and information on global pandemic

  • http://hivinsite.ucsf.edu/

    HIV information from UCSF, including "Molecular Insights into HIV"

  • http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books

    The NCBI Bookshelf is a growing collection of biomedical books that can be searched directly. For example, in the book Immunology, many HIV-related figures and images are presented alongside detailed information on HIV biology

  • http://www.thebody.com/index.html

    HIV/AIDS information in more than 550 topic areas

  • http://www.cdcnpin.org/scripts/hiv/index.asp

    National Prevention Information Network

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    • Value Proposition
    • #ThanksResearch
    • Annual Awards: Buster & Nancy D. Alvord, and Alvin J. Thompson
    • Member Job Postings
    • Sponsorship Opportunities
  • Events & Programs
    • 2026 IACUC & IBC Conferences
    • 2025-2026 Advocacy Efforts
    • Leadership Awards Gala - 9/25/25
    • Call for 2026 Conference Submissions
    • 2025 Clinical Research Professional Conference
    • 2024 IBC, Biomedical Data and IP Security, and IACUC Conferences
    • 2023 #ThanksResearch Gala
    • 2023 October 19th Communication Workshop
    • 2026 Camp BIOmed
    • Topical Webinars
    • Community Events
    • CyberBio 2025
    • Conference and Event Policies
    • 2024 Portland Clinical Research Professionals Conference
    • 2023 #ThanksResearch Gala
    • 2023 Hybrid Communication Workshop
    • Topical Webinars
    • Community Events
    • Conference and Event Policies
    • 2025 IRB, IBC, IACUC Conference Series
  • Teacher Center
    • Ethics Primer
    • Bioethics 101
    • Introductory Bioinformatics: Genetic Testing
    • Advanced Bioinformatics: Genetic Research
    • The Nature of Scientific Research
    • Animals in Research
    • Humans in Research
    • Stem Cell Research
    • HIV Vaccines
    • Consumer Awareness
    • For the Greater Good
    • Education Strategies
  • Resources
    • General Resources
    • Student Resources
    • Research Resources
    • Useful Links
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